Postorgasmic Illness Syndrome: When the ‘Big O’ Makes You Sick.

Medically Reviewed by Justin Laube, MD on 
October 10, 2023


Have you ever experienced flu-like symptoms like fever, foggy head, painful muscles or joints, fatigue, or problems concentrating right after having sex? You could have postorgasmic illness syndrome (POIS), a condition first identified in 2002 that tends to affect men shortly after ejaculation (it also, rarely, may occur in females).

According to a study, there are indications that POIS is triggered in a man by an autoimmune reaction to his own seminal fluid (in women, it’s associated with tissue around the vagina). If you think POIS could be putting a damper on your sex life, it’s time to talk to a urologist or gynecologist.

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