11/21/2023
Evangelyn Rodriguez
In human colon cancer cell lines, treatment with curcumin results in reduced viability and proliferation, suggesting that the compound has a cytotoxic effect on cancer cells.
One of the ways through which curcumin causes cytotoxicity in cancer cells is by enhancing ROS production, which triggers apoptosis and the breakdown of mitochondrial membranes. A study by researchers at the Ludwig Maximillian University of Munich also found that ROS can activate a signaling pathway that triggers the production of miR-34, a microRNA molecule that plays a critical role in tumor suppression.
In a phase II open-labeled randomized controlled trial, researchers compared how patients with inoperable metastatic colorectal cancer who were undergoing treatment fared with or without daily curcumin supplementation. They reported that taking curcumin improved overall survival among the participants, suggesting that curcumin can be used as an adjunct to chemotherapy for the treatment of advanced colorectal carcinoma.
-
Tags
#Cancer